Overall, cognitive domains often found to be impaired were EFs, attention, and memory.Ĭonclusion: Cognitive sequelae in patients with post-infective SARS-CoV-2 can be detected with NPs testing. Remotely-delivered tests yielded lower percentages of cognitive impairment. Among second-level tests, those assessing attention and executive functions (EFs) were highly represented. The most frequently administered screeners were the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE)-with the former more likely to detect mild, and the latter moderate/severe deficits. Results: The majority of studies ( N = 13) adopted first-level tests. From 711 retrieved articles, 19 studies conducted on patients with SARS-CoV-2 without medical comorbidities were included and stratified by disease severity. Observational studies quantitatively assessing cognition in patients with post-infective SARS-CoV-2 were considered. Methods: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and was pre-registered on Prospective Register of Systematic Reviews (PROSPERO) (CRD42021253079). The present work reviewed published studies to provide a critical narrative of neuropsychological (NPs) deficits commonly observed after SARS-CoV-2 infection and the tests most suited for detecting such cognitive sequelae depending on illness severity. However, little is known about which cognitive alterations are commonly found in patients recovered from SARS-CoV-2, and which psychometric tools clinicians should consider when assessing cognition in this population. 7Department of Anaesthesia and Critical Care, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italyīackground: Patients with post-infective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) often show both short- and long-term cognitive deficits within the dysexecutive/inattentive spectrum.6Department of Psychology, University of Milano-Bicocca, Milan, Italy.5Laboratory of Acute Brain Injury and Therapeutic Strategies, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.4School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.3University of Milano-Bicocca, Milan, Italy.2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.1Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy.Zanier 5 Nino Stocchetti 2,7 Paolo Brambilla 1,2 Bruno Biagianti 1,2* Asia Di Liberto 1 Aiello Nicolò Edoardo 3,4 Ilaria Lisi 5 Letizia Nobilia 6 Giulia Delor de Ferrabonc 1 Elisa R.
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